Реакция #60945

ord-c9004957395c4b36b36d5524809b962c

Уравнение реакции

CS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-methanesulfonyl-benzoic acid
O=C(O)c1cc(S(=O)O)ccc1Cl
2-Chloro-5-sulfino-benzoic acid
CC(C)I
2-iodopropane
→
CC(C)S(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
title compound
Выход 42.0%
CC(C)S(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-(propane-2-sulfonyl)-benzoic acid
Выход 42.0%

Реактанты

CS(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-methanesulfonyl-benzoic acid
O=C(O)c1cc(S(=O)O)ccc1Cl
2-Chloro-5-sulfino-benzoic acid
CC(C)I
2-iodopropane

Реагенты

Нет

Растворители

O
water

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеobtained in 42% yield

Методика

The title compound was synthesised according to the procedure described for the synthesis of 2-Chloro-5-methanesulfonyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and 2-iodopropane in 20 ml water and obtained in 42% yield. MS (m/e): 261.1 (MH−, 100%).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07427612B2uspto-grants-2008_09