Реакция #60793

Уравнение реакции

DIPEA

methyl [(6chloro-5-formylpyrimidin-4-yl)thio]acetate

intermediate 9

methyl [(6chloro-5-formylpyrimidin-4-yl)thio]acetate

→

title compound

Выход 53.9%

Methyl 4-chlorothieno[2,3-d]pyrimidine-6-carboxylate

Выход 53.9%

Растворители

cyclohexanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated
2. 2
   Другоеthe product purified by flash chromatography on silica eluting with hexane:diethyl ether (4:1)

Методика

DIPEA (2.1 mL) was added to methyl [(6chloro-5-formylpyrimidin-4-yl)thio]acetate (intermediate 9) (2.9 g) in cyclohexanol (50 mL) under an inert atmosphere. The reaction mixture was heated at 120° C. for 90 minutes. The solvent was evaporated and the product purified by flash chromatography on silica eluting with hexane:diethyl ether (4:1) to afford the title compound as a pale yellow solid (1.45 g, 53%);

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