Реакция #60752

Уравнение реакции

4-(4-acetamidophenyl)-2-amino-3-cyanofurane

4-(4-Acetamidophenyl)-2-amino-3-cyanofurane

diethoxymethyl acetate

→

6

Выход 52.9%

4-(4-Acetamidophenyl)-3-cyano-2-[(ethoxymethylidene)amino]furane

Выход 52.9%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   Концентрированиеconcentrated (below 40° C. in water bath)
3. 3
   ДругоеThe residual paste was dried up with a pump
4. 4
   ДругоеThe dried solid material was triturated with ether
5. 5
   Фильтрацияthen filtrated

Методика

At room temperature, to the mixture of 4-(4-acetamidophenyl)-2-amino-3-cyanofurane 5 (6.0 g, 25 mmol) in acetic acid (60 mL), diethoxymethyl acetate (41 mL, 25 mmol) was added dropwise. The mixture was stirred at room temperature for 30 min and then concentrated (below 40° C. in water bath). The residual paste was dried up with a pump. The dried solid material was triturated with ether then filtrated to afford 6 (3.93 g) as a solid. MS(ES) m/e 298 [M+H].

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