Реакция #60704

Уравнение реакции

water

3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

potassium carbonate

2-bromo-1-fluoroethane

→

title compound

Выход 32.9%

3-Chloro-N-[1-(2-chlorophenyl)-2-[1-(2-fluoroethyl)-piperidin-4-ylmethoxy]ethyl]-1H-indole-6-carboxamide

Выход 32.9%

Растворители

DMSO

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Другоеthe resulting precipitate was isolated by filtration
3. 3
   ДругоеPurification of the filtrate (SiO2: EtOAc)

Методика

To a solution of 3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.3 mmol) in 6 mL of DMSO was added potassium carbonate (716 mg, 5.2 mmol) and 2-bromo-1-fluoroethane (0.10 mL, 1.1 mmol). The reaction was allowed to stir at room temperature overnight after which time water was added and the resulting precipitate was isolated by filtration. Purification of the filtrate (SiO2: EtOAc) provided 178 mg (28%) of the title compound.

Источник