Реакция #60685

Уравнение реакции

4-[2-amino-2-(2-pyridinyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester

3-chloroindole-6-carboxylic acid

→

4-{2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-(2-pyridinyl)-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester

Условия реакции

Обработка

1. 1
   Другоеafforded
2. 2
   Другоеafter purification (SiO2: 10 DCM:2 EtOAc:2 Hexane:0 to 1.5 isopropyl amine), 835 mg (64%) of the title compound

Методика

Using coupling method A, 4-[2-amino-2-(2-pyridinyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester (730 mg, 2.2 mmol) and 3-chloroindole-6-carboxylic acid (468 mg, 2.4 mmol) afforded, after purification (SiO2: 10 DCM:2 EtOAc:2 Hexane:0 to 1.5 isopropyl amine), 835 mg (64%) of the title compound.

Источник