Реакция #60660

Уравнение реакции

5-(3-Aminopropyl)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]imidazolidine-2,4-dione trifluoroacetic acid

DIPEA

Sulfonylchloride

→

N-{3-{4-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl}methyl]-2,5-dioxoimidazolidin-4-yl}propyl)methanesulfonamide

Растворители

DCM

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe reaction was stirred at rt over night
2. 2
   ДругоеThe crude product was purified by preparative HPLC

Методика

5-(3-Aminopropyl)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]imidazolidine-2,4-dione trifluoroacetic acid (100 mg, 0.18 mmol) was slurried in 2 mL DCM. DIPEA (62 μL, 0.36 mmol) was added and the slurry was stirred for some minutes. Sulfonylchloride (16 μL, 0.18 mmol) was added and the reaction was stirred at rt over night. The crude product was purified by preparative HPLC.

Источник