Реакция #6047

Уравнение реакции

[2R,3R]-2,3-Bis(((1,1-dimethylethyl)dimethylsilyl)oxymethyl)cyclobutanone

methoxylamine hydrochloride

→

title compound

Выход 75.7%

[2R,3R]-2,3-Bis(((1,1-dimethylethyl)dimethylsilyl)oxymethyl)-cyclobutanone O-methyl oxime

Выход 75.7%

Растворители

pyridine

pyridine

Условия реакции

Обработка

1. 1
   Концентрированиеit was concentrated to approximately 1/4 of the original volume
2. 2
   workup.ADDITIONthen diluted with ethyl acetate
3. 3
   Промывкаwashed with saturated aqueous sodium bicarbonate solution
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated in vacuo
7. 7
   ДругоеThe residue was purified by flash chromatography on a 5×38 cm silica gel column
8. 8
   Промывкаeluted with 1 L of hexane and 5% acetone in hexane

Методика

A solution of 12.317 g (34.9 mmol) of [2R,3R]-2,3-Bis(((1,1-dimethylethyl)dimethylsilyl)oxymethyl)cyclobutanone, from Step E, in 20 mL of pyridine was added to a solution of 3.160 g (37.8 mmol) of methoxylamine hydrochloride in 80 mL of pyridine. After stirring the reaction mixture for 70 min at ambient temperature, it was concentrated to approximately 1/4 of the original volume then diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography on a 5×38 cm silica gel column eluted with 1 L of hexane and 5% acetone in hexane to give 10.228 g (75.7% yield) of the title compound as a mixture of geometrical isomers. .MS DCI-NH3M/Z: 388 (M+H)+.

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