Реакция #60342

Уравнение реакции

tert-Butyl-chloro-dimethyl-silane

4-chromanol

N-methylmorpholine

imidazole

→

title compound

tert-butyl-(chroman-4-yloxy)-dimethyl-silane

Растворители

CH2Cl2

CH2Cl2

Условия реакции

Обработка

1. 1
   Промывкаwashed with dilute HCl and H2O
2. 2
   Сушкаdried over MgSO4
3. 3
   Фильтрацияfiltered
4. 4
   Концентрированиеconcentrated in vacuo

Методика

tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.

Источник