Реакция #600394

Уравнение реакции

water

methyl bromopyruvate

3-chloropyrazin-2-amine

sodium bicarbonate

→

title compound

Выход 70.7%

methyl 8-chloroimidazo[1,2-a]pyrazine-2-carboxylate

Выход 70.7%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураcooled to r.t
2. 2
   ФильтрацияThe resulting solids were filtered
3. 3
   Другоеazeotroped with EtOAc (2 L)
4. 4
   Другоеdried overnight at 40° C. under vacuum and nitrogen sweep

Методика

To a solution of 3-chloropyrazin-2-amine (52 g, 401 mmol) in acetonitrile (750 mL) under N2 was added sodium bicarbonate (67.4 g, 803 mmol), and then methyl bromopyruvate (97 mL, 803 mmol). The mixture was then heated to 80° C. for 4 hours and then cooled to r.t. The reaction was then diluted water (2200 mL) and stirred for 30 minutes. The resulting solids were filtered, azeotroped with EtOAc (2 L), and dried overnight at 40° C. under vacuum and nitrogen sweep to give the title compound (60 g). LRMS (ESI) calc (M+H)+=212.0. found 212.0

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