Реакция #60030

Уравнение реакции

2,4-Dichlorophenacyl chloride

imidazole

→

1-(2,4-dichlorophenyl)-2-imidazolylethan-1-one

Растворители

toluene

Условия реакции

Обработка

1. 1
   КонцентрированиеThe mixture was concentrated to dryness in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane
3. 3
   Промывкаwashed with 5% aqueous potassium carbonate solution and water
4. 4
   Другоеdried
5. 5
   Концентрированиеconcentrated in vacuo
6. 6
   ДругоеThe crude product was purified by passage over a pad of silica gel
7. 7
   Промывкаeluting with 5% methanol in dichloromethane

Методика

2,4-Dichlorophenacyl chloride (1.42 g, 6.4 mmol) and imidazole (1.18 g, 16 mmol) were heated in toluene (40 ml) at 75° C. for 2.25 hours. The mixture was concentrated to dryness in vacuo. The residue was dissolved in dichloromethane and washed with 5% aqueous potassium carbonate solution and water, dried and concentrated in vacuo. The crude product was purified by passage over a pad of silica gel, eluting with 5% methanol in dichloromethane to give 1-(2,4-dichlorophenyl)-2-imidazolylethan-1-one as an orange oil.

Источник