Реакция #600101

Уравнение реакции

methyl magnesium chloride

2-hydroxy acetophenone

THF

acetic acid

→

hydroxy phenol

Выход 45.0%

2-(1-Hydroxy-1-methyl-ethyl)-phenol

Выход 45.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеkept under nitrogen, at 0° C.
2. 2
   ДругоеAfter completion of the reaction

Методика

To a stirred solution of methyl magnesium chloride (134 ml, 3M in THF) kept under nitrogen, at 0° C. was added a solution of 2-hydroxy acetophenone (50 g, 367 mmol) in anhydrous THF (100 ml). The reaction mixture was stirred. After completion of the reaction, the reaction mixture was treated with 4M acetic acid (500 ml) followed by usual workup in dichloromethane and FC to give hydroxy phenol 31 (25 g, 45%) as a colorless oil.

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