Реакция #599729

Уравнение реакции

4-isothiocyanatoquinoline

2-amino-cyanoacetamide

→

titled compound

5-amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

Растворители

EtOAc

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 90 min
2. 2
   КонцентрированиеThe reaction mixture was concentrated in vacuo
3. 3
   Другоеthe resulting solids were collected
4. 4
   Промывкаwashed with EtOAc

Методика

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

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