Реакция #599721

Уравнение реакции

6-isothiocyanatoquinoline

2-amino-cyanoacetamide

→

titled compound

Выход 65.4%

5-amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide

Выход 65.4%

Растворители

EtOAc

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 90 min
2. 2
   КонцентрированиеThe reaction mixture was concentrated in vacuo
3. 3
   Другоеthe residue was purified by silica gel column chromatography
4. 4
   Промывкаeluted with 2% MeOH in DCM

Методика

A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.

Источник