Реакция #599706

Уравнение реакции

2-amino-2-cyanoacetamide

1-isothiocyanatonaphthalene

→

titled compound

Выход 48.7%

5-amino-2-(naphthalen-1-ylamino)thiazole-4-carboxamide

Выход 48.7%

Растворители

EtOAc

Условия реакции

Обработка

1. 1
   Температураthe mixture was refluxed for 30 min
2. 2
   ДругоеThe solvent was evaporated under reduced pressure
3. 3
   Другоеthe resulting crude residue was purified by silica gel column chromatography
4. 4
   Промывкаeluted with 2% MeOH in DCM

Методика

To a suspension of 2-amino-2-cyanoacetamide (0.25 g, 2.53 mmol) in EtOAc (8 mL), was added 1-isothiocyanatonaphthalene (0.467 g, 2.53 mmol), and the mixture was refluxed for 30 min. The solvent was evaporated under reduced pressure, and the resulting crude residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.35 g (48% yield) of the titled compound.

Источник