Реакция #59933

Уравнение реакции

Magnesium sulfate

sodium hydroxide

lithium aluminum hydride

ethyl(2-ethyl-1,3-dioxolan-2-yl)acetate

→

title compound

Выход 92.1%

2-(2-ethyl-1,3-dioxolan-2-yl)ethanol

Выход 92.1%

Растворители

water

water

tetrahydrofuran

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added under ice-
2. 2
   Температураcool
3. 3
   Температураcooled on ice
4. 4
   Температураcool
5. 5
   Фильтрацияfiltrated through silica gel
6. 6
   КонцентрированиеThe filtrate was concentrated under reduced pressure

Методика

To a tetrahydrofuran (50 ml) suspension of lithium aluminum hydride (800 mg, 21.1 mmol), ethyl(2-ethyl-1,3-dioxolan-2-yl)acetate (3.85 g, 20.5 mmol) was added under ice-cool. The mixture was stirred at room temperature for one hour and 30 minutes and cooled on ice. Thereafter, water (0.8 ml), a 15% aqueous sodium hydroxide solution (0.8 ml), and water (2.4 ml) were sequentially added to the mixture under ice cool. Magnesium sulfate was added to the mixture and filtrated through silica gel. The filtrate was concentrated under reduced pressure to obtain the title compound (2.76 g, 92.1%) as an oil.

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