Реакция #595396

Уравнение реакции

p-tolylhydrazine hydrochloride

1-carbethoxy-4-piperidone

→

desired product

Выход 86.0%

Ethyl 8-Methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Выход 86.0%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураto reflux for 2 hours
3. 3
   ДругоеThe reaction mixture was removed
4. 4
   Температураfrom heat
5. 5
   ФильтрацияThe resulting mixture was filtered
6. 6
   Промывкаwashed with 50% aqueous EtOH

Методика

Following a literature procedure (Harbert et al., J. Med. Chem. 1980, 23, 635-643) p-tolylhydrazine hydrochloride (0.500 g, 3.15 mmol) and 1-carbethoxy-4-piperidone (0.18 mL, 1.17 mmol) were suspended in EtOH (0.880 mL) and heated to reflux for 2 hours. The reaction mixture was removed from heat and allowed to stand overnight at ambient temperature. The resulting mixture was filtered and washed with 50% aqueous EtOH to afford the desired product as a beige powder (259 mg, 86%).

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