Реакция #595388

Уравнение реакции

benzyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-(hydroxymethyl)benzoate

Dess-Martin periodinane

→

benzyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-formylbenzoate

Растворители

H2O

DCM

Условия реакции

Обработка

1. 1
   Экстракцияextracted with DCM
2. 2
   ПромывкаThe combined organic layers were washed with brine
3. 3
   Сушкаdried over Na2SO4
4. 4
   Концентрированиеconcentrated
5. 5
   ДругоеThe resulting crude oil was used in the next step without further purification

Методика

To a mixture of benzyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-(hydroxymethyl)benzoate (G-3) (0.4 g, 0.71 mmol) in DCM (10 mL) was added Dess-Martin periodinane (0.45 g, 1.07 mmol), and the mixture was stirred at rt for 24 h. The mixture was diluted with H2O and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The resulting crude oil was used in the next step without further purification. LCMS (ESI)′ calc'd for C30H19ClF3N2O4 [M+H]+: 563. found: 563.

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