Реакция #595386

Уравнение реакции

(3-bromo-1H-indazol-1-yl)(2-chloro-6-(trifluoro methyl)phenyl)methanone

K2CO3

→

title compound

5-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)isobenzo furan-1 (3H)-one

Растворители

H2O

H2O

1,4-dioxane

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was cooled to rt
2. 2
   ЭкстракцияThe aqueous layer was extracted with EtOAc
3. 3
   ПромывкаThe combined organic layers were washed with brine
4. 4
   Сушкаdried over Na2SO4
5. 5
   Концентрированиеconcentrated
6. 6
   ДругоеThe residue was purified by flash chromatography (PE:EA=4:1)

Методика

(0.97 g, 2.48 mmol), (3-bromo-1H-indazol-1-yl)(2-chloro-6-(trifluoro methyl)phenyl)methanone (1.0 g, 2.48 mmol), K2CO3 (1.03 g, 7.44 mmol) and Pd(PPh3)4 (0.143 g, 0.12 mmol) were suspended in 1,4-dioxane (15 mL) and H2O (3 mL). The reaction mixture was heated at 100° C. in a microwave reactor for 2 h. The reaction mixture was cooled to rt and diluted with H2O. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The residue was purified by flash chromatography (PE:EA=4:1) to afford the title compound as a pale yellow oil. LCMS (ESI) calc'd for C23H13ClF3N2O3 [M+H]+: 457. found: 457.

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