Реакция #595376

Уравнение реакции

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

Выход 97.4%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   КонцентрированиеAfter completion the reaction mixture was concentrated under reduced pressure
2. 2
   Другоеthe product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

Методика

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

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