Реакция #595370

Уравнение реакции

4-bromo-2-fluoro-5-methylbenzoic acid

SOCl2

CH3OH

→

title compound

methyl 4-bromo-2-fluoro-5-methylbenzoate

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed in vacuo
2. 2
   workup.ADDITIONthe residue was diluted with EtOAc
3. 3
   Промывкаwashed with H2O, brine
4. 4
   Сушкаdried over anhydrous Na2SO4
5. 5
   Концентрированиеconcentrated
6. 6
   ПромывкаThe resulting crude solid was washed with PE

Методика

To a solution of 4-bromo-2-fluoro-5-methylbenzoic acid (i-2a) (1.87 g, 8 mmol) in CH3OH (50 mL) at 0° C. was added SOCl2 (6 mL, 80 mmol) dropwise. Then the mixture was heated to 80° C. for 2 h. The solvent was removed in vacuo and the residue was diluted with EtOAc and washed with H2O, brine, dried over anhydrous Na2SO4, and concentrated. The resulting crude solid was washed with PE to give the title compound as a yellow solid. 1H NMR (400 MHz, CDCl3) δ 7.80 (1H, d), 7.37 (1H, d), 3.92 (3H, s), 2.39 (3H, s).

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