Реакция #595353

Уравнение реакции

compound

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

thionyl chloride

→

Methyl 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole-5-carboxylate

Условия реакции

Обработка

1. 1
   ДругоеThe excess thionyl chloride is removed under reduced pressure
2. 2
   ПромывкаThe mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   СушкаThe organic phase is dried over magnesium sulfate
4. 4
   Другоеthe solvent is removed under reduced pressure
5. 5
   ДругоеThe product obtained
6. 6
   Другоеis used without further purification in the subsequent reactions

Методика

100 mg (0.43 mmol) of the compound from Example 44A, together with 0.24 ml (3.24 mmol) of thionyl chloride, are stirred at RT for 8 h. The excess thionyl chloride is removed under reduced pressure and the residue is taken up in about 5 ml of ethyl acetate. The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure. The product obtained is used without further purification in the subsequent reactions.

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