Реакция #595352

Уравнение реакции

compound

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

hydrochloric acid

→

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

Растворители

methanol

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted three times with in each case 10 ml of diethyl ether
2. 2
   СушкаThe combined organic phases are dried over magnesium sulfate
3. 3
   Другоеthe solvent is removed on a rotary evaporator
4. 4
   ДругоеThe product obtained
5. 5
   Другоеis used without further purification in the subsequent reaction

Методика

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

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