Реакция #595347

Уравнение реакции

compound

[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

Условия реакции

Обработка

1. 1
   Другоеexcess thionyl chloride is then removed under reduced pressure
2. 2
   Промывкаwashed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   СушкаThe organic phase is dried over magnesium sulfate
4. 4
   Другоеthe solvent is removed on a rotary evaporator
5. 5
   ДругоеThe product obtained
6. 6
   Другоеis used without further purification in the subsequent reactions

Методика

269 mg (0.77 mmol) of the compound from Example 38A are initially charged in 0.43 ml (5.85 mmol) of thionyl chloride. The reaction mixture is stirred at RT for 12 h, and excess thionyl chloride is then removed under reduced pressure. The residue is taken up in 5 ml of ethyl acetate and washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reactions.

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