Реакция #595321

Уравнение реакции

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

Выход 71.0%

Butyl cyclopropanesulfonate

Выход 71.0%

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was slowly warmed at room temperature
2. 2
   ДругоеThe solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   ПромывкаThe organic phase was washed with water, brine
5. 5
   Сушкаdried (MgSO4)
6. 6
   Концентрированиеconcentrated

Методика

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

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