Реакция #59413

ord-6e218ee8606c409ebe141bed79bde1d9

Уравнение реакции

Cl.N[C@H]1COc2ccccc2NC1=O
(S)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt
CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O
N-t-butyloxycarbonyl-L-serine
CC(C)(C)OC(=O)N[C@H](CO)C(=O)O
N-t-butyloxycarbonyl-D-serine
→
Cl.N[C@@H]1COc2ccccc2NC1=O
(R)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt

Реактанты

Cl.N[C@H]1COc2ccccc2NC1=O
(S)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt
CC(C)(C)OC(=O)N[C@@H](CO)C(=O)O
N-t-butyloxycarbonyl-L-serine
CC(C)(C)OC(=O)N[C@H](CO)C(=O)O
N-t-butyloxycarbonyl-D-serine

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

(R)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt was prepared from N-t-butyloxycarbonyl-D-serine by the procedures described in Itoh, et al., Chem. Pharm. Bull. 1986, 34, 1128-1147 for the preparation of (S)-3-amino-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride salt from N-t-butyloxycarbonyl-L-serine.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07425550B2uspto-grants-2008_09