Реакция #592255

Уравнение реакции

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

Выход 27.0%

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

Выход 27.0%

Растворители

DCE

Условия реакции

Обработка

1. 1
   Концентрированиеthe mixture was concentrated in vacuo
2. 2
   Другоеpurified by prep

Методика

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.

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