Реакция #59072

Уравнение реакции

3-(tert-butyl)phenylamine

sodium bicarbonate

thiophosgene

→

3-(tert-butyl)benzenisothiocyanate

Растворители

acetone

Условия реакции

Обработка

1. 1
   Другоеwas brought to ambient temperature
2. 2
   Концентрированиеconcentrated
3. 3
   Другоеpartitioned between ethyl acetate and water
4. 4
   СушкаThe organic layer was dried with sodium bicarbonate and sodium sulfate
5. 5
   Концентрированиеconcentrated

Методика

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

Источник