Реакция #59025

Уравнение реакции

Water

Ethyl bromoacetate

5-bromo-2-hydroxyacetophenone

potassium carbonate

→

ethyl (2-acetyl-4-bromophenoxy)acetate

Растворители

ethyl acetate

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture was stirred at that temperature overnight
2. 2
   ДругоеThe organic layer was separated
3. 3
   Промывкаwashed with water and brine
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   ДругоеThe solvent was evaporated under reduced pressure

Методика

Ethyl bromoacetate (0.62 mL) was added to a mixture of 5-bromo-2-hydroxyacetophenone (1.0 g) and potassium carbonate (0.96 g) in N,N-dimethylformamide (10 mL) at room temperature with stirring, and the mixture was stirred at that temperature overnight. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford ethyl (2-acetyl-4-bromophenoxy)acetate as a crude product.

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