Реакция #59019

Уравнение реакции

hydrochloric acid

Trifluoromethanesulfonic anhydride

methyl 4-hydroxy-2-methoxybenzoate

pyridine

→

methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate

Растворители

ethyl acetate

methylene chloride

Условия реакции

Обработка

1. 1
   Температураcooled
2. 2
   workup.STIRRINGThe mixture was stirred at room temperature for 30 min
3. 3
   ЭкстракцияThe resulting mixture was extracted with ethyl acetate
4. 4
   ПромывкаThe organic layer was washed with water and brine
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   ДругоеThe solvent was evaporated under reduced pressure

Методика

Trifluoromethanesulfonic anhydride (2.24 mL) was added to an ice-cooled mixture of methyl 4-hydroxy-2-methoxybenzoate (2.02 g) and pyridine (0.14 mL) in methylene chloride (15 mL) with stirring. The mixture was stirred at room temperature for 30 min, and poured into a mixture of hydrochloric acid and ethyl acetate. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate (3.49 g).

Источник