Реакция #589847

Уравнение реакции

Triethylamine

hydroxyacetophenone

malononitrile

→

product

Выход 49.0%

2-Amino-4-phenyl-furan-3-carbonitrile

Выход 49.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was then evaporated onto silica
2. 2
   Другоеpurified by flash column chromatography (20% acetone/hexane)

Методика

To a solution of hydroxyacetophenone (10 g, 73.2 mmol) in methanol (200 mL) was added malononitrile (4.85 g, 73.4 mmol). Triethylamine (10.23 mL, 73.3 mmol) was then added slowly. The resulting dark solution was stirred overnight at room temperature. The mixture was then evaporated onto silica and purified by flash column chromatography (20% acetone/hexane) to afford the product as a pale yellow solid (6.6 g, 49%).

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