Реакция #588166

Уравнение реакции

3-Chloro-2-aminopyrazine

methyl 2-chloro-3-oxopentanoate

→

title compound

Выход 25.5%

8-Chloro-2-ethylimidazo[1,2-a]pyrazine-3-carboxylic Acid Methyl Ester

Выход 25.5%

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураto cool
3. 3
   Фильтрацияthe unnecessary materials were filtered off
4. 4
   Промывкаwashed with ethyl acetate
5. 5
   Другоеevaporated
6. 6
   ДругоеThe resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1)

Методика

3-Chloro-2-aminopyrazine (2.1 g, 16.2 mmol) and methyl 2-chloro-3-oxopentanoate (6.7 mL, 48.6 mmol) were mixed, and heated under stirring at 170° C. for 2 hours. After being allowed to cool, the unnecessary materials were filtered off and washed with ethyl acetate, and then filtrates were combined and evaporated. The resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1) to give the title compound (0.99 g) as white crystals.

Источник