Реакция #587741

Уравнение реакции

5-bromo-2-(2,4-dichlorophenylamino)-3,4-difluorobenzoic acid methyl ester

NaN3

→

desired product

Выход 96.2%

4-azido-5-bromo-2-(2 4-dichlorophenylamino)-3-fluorobenzoic acid methyl ester

Выход 96.2%

Растворители

EtOAc

DMA

Условия реакции

Обработка

1. 1
   Промывкаwashed with water (5×)
2. 2
   СушкаThe organic layer was dried over MgSO4
3. 3
   Фильтрацияfiltered
4. 4
   Концентрированиеconcentrated in vacuo

Методика

A mixture of 5-bromo-2-(2,4-dichlorophenylamino)-3,4-difluorobenzoic acid methyl ester (2.02 g, 4.91 mmol) and NaN3 (379 mg, 5.83 mmol) in DMA (40 mL) was heated at 50° C. for 3 hours. The reaction mixture was diluted with EtOAc, and washed with water (5×). The organic layer was dried over MgSO4, filtered, and concentrated in vacuo to give the desired product (2.05 g, 96%) that was used directly without further purification.

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