Реакция #586150

Уравнение реакции

4-ethoxy-3-methyl-1,1,1-trifluoro-3-buten-2-on

hydrazine hydrate

→

4-methyl-3-trifluoromethylpyrazol

Выход 86.7%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe ethanol was distilled off under reduced pressure
2. 2
   Другоеthe residue was separated with ethyl acetate and water
3. 3
   ПромывкаThe organic layer was washed with water twice
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Методика

1.7 g (10.2 mmol) of 4-ethoxy-3-methyl-1,1,1-trifluoro-3-buten-2-on and 0.6 g (12.0 mmol) hydrazine hydrate were stirred in 50 ml of ethanol at room temperature for 2 hours. The ethanol was distilled off under reduced pressure, and the residue was separated with ethyl acetate and water. The organic layer was washed with water twice and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 1.3 g of 4-methyl-3-trifluoromethylpyrazol (yield 86.7%).

Источник