Реакция #586113

Уравнение реакции

N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide

→

N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide

Выход 85.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеIn a flask equipped with a magnetic stirring bar
2. 2
   ДругоеNitrogen is bubbled through the solution and 10% Pd on charcoal
3. 3
   workup.ADDITIONis added
4. 4
   ДругоеAfter flushing with nitrogen
5. 5
   ДругоеThe suspension is flushed with nitrogen
6. 6
   Фильтрацияfiltered
7. 7
   Промывкаrinsed over Celite
8. 8
   КонцентрированиеThe filtrate is concentrated under vacuum

Методика

In a flask equipped with a magnetic stirring bar and a rubber septum is dissolved the N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide in methanol. Nitrogen is bubbled through the solution and 10% Pd on charcoal is added. After flushing with nitrogen, the suspension is placed under hydrogen atmosphere and stirred for 2 hours. The suspension is flushed with nitrogen and filtered and rinsed over Celite. The filtrate is concentrated under vacuum. In this fashion is obtained N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide (85%).

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