Реакция #586100

Уравнение реакции

product

2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene

hydrogen

→

2-(2-aminophenyl)-3-(trimethylsilyl)-propane

Выход 88.0%

Растворители

tetrahydrofurane

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was filtered off
2. 2
   Другоеafter evaporation of the solvent
3. 3
   Другоеthe product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

Методика

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

Источник