Реакция #58460

ord-6dcbf1f49ea5451f9f935ed91bf27ad3

Уравнение реакции

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
N#Cc1cccc(C(=O)CBr)c1
2-bromo-3′-cyanoacetophenone
→
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1cccc(C#N)c1
title compound
Выход 82.7%
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1cccc(C#N)c1
(RS)-2-[2-(3-Cyano-phenyl)-2-oxo-ethoxycarbonylmethyl]-piperidine-1-carboxylic tert butyl ester
Выход 82.7%

Реактанты

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
N#Cc1cccc(C(=O)CBr)c1
2-bromo-3′-cyanoacetophenone

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound (1.51 g) was prepared from (RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (1.15 g) and 2-bromo-3′-cyanoacetophenone (1.06 g) according to the method of description 36.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07423052B2uspto-grants-2008_09