Реакция #58459

ord-c95c2991bde54740a6af9825fb19498d

Уравнение реакции

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
O=C(CBr)c1cccc(Cl)c1
2-bromo-3′-chloroacetophenone
→
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1cccc(Cl)c1
title compound
Выход 81.4%
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1cccc(Cl)c1
(RS)-2-[2-(3-Chloro-phenyl)-2-oxo-ethoxycarbonylmethyl]-piperidine-1-carboxylic tert butyl ester
Выход 81.4%

Реактанты

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
O=C(CBr)c1cccc(Cl)c1
2-bromo-3′-chloroacetophenone

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound (2.65 g) was prepared from (RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (2.0 g) and 2-bromo-3′-chloroacetophenone (1.92 g) according to the method of description 36.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07423052B2uspto-grants-2008_09