Реакция #58422

Уравнение реакции

3-chloro-4-fluoroanisole

iodine

→

5-chloro-4-fluoro-2-iodoanisole

Выход 59.8%

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered through Celite
2. 2
   ПромывкаThe filtrate was washed with water, brine
3. 3
   Другоеdried
4. 4
   Концентрированиеconcentrated
5. 5
   ДругоеThe crude product was purified by crystallization from ether/petroleum ether

Методика

To a solution of 3-chloro-4-fluoroanisole (4.69 g, Lancaster) in chloroform (250 mL) was added silver trifluoroacetate (23.2 g, Aldrich) followed by iodine (15.8 g, Aldrich) in several portions. The reaction mixture was stirred for 2 hours and filtered through Celite. The filtrate was washed with water, brine, dried and concentrated. The crude product was purified by crystallization from ether/petroleum ether to give 5-chloro-4-fluoro-2-iodoanisole (5.0 g). MS (M+H)+, 285.

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