Реакция #58371

Уравнение реакции

hydrochloric acid

1-bromo-3-methylbut-2-ene

2-hydroxy-5-methoxybenzaldehyde

potassium carbonate

→

5-methoxy-2-(3 -methylbut-2-enyloxy)benzaldehyde

Растворители

ethyl acetate

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   Промывкаthe organic layer was washed with water three times
2. 2
   Сушкаdried over magnesium sulfate
3. 3
   ФильтрацияThe mixture was filtered
4. 4
   Другоеsolvent removed from the filtrate under reduced pressure

Методика

To a solution of 2-hydroxy-5-methoxybenzaldehyde (7.6 g, 50 mmol) in dry N,N-dimethylformamide (100 mL) was added potassium carbonate (10.4 g), followed by 1-bromo-3-methylbut-2-ene (10.0 g, 67 mmol). The mixture was stirred at room temperature for 48 hours and ethyl acetate added. Sufficient 1M hydrochloric acid was cautiously added to neutralize the base, and the organic layer was washed with water three times, followed by brine, and dried over magnesium sulfate. The mixture was filtered, and solvent removed from the filtrate under reduced pressure, to provide 5-methoxy-2-(3 -methylbut-2-enyloxy)benzaldehyde.

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