Реакция #5831

Уравнение реакции

water

p-chlorocinnamyl chloride

2,3-diaminopyridine

potassium carbonate

→

title compound

Выход 42.2%

2-Amino-3-(4-Chlorocinnamylamino)Pyridine

Выход 42.2%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Экстракцияextracted twice with 200 ml of chloroform
2. 2
   СушкаThe extract was dried over magnesium sulfate
3. 3
   Концентрированиеconcentrated under a reduced pressure
4. 4
   Другоеresulting residue
5. 5
   Промывкаeluted with chloroform/methanol (100:1 to 50:1)

Методика

7.71 g of p-chlorocinnamyl chloride and 13.5 g of 2,3-diaminopyridine were dissolved in 220 ml of dimethylformamide, and to the solution was added 8.6 g of potassium carbonate, and the mixture was stirred at a room temperature for 50 hours, and after adding 300 ml of water, extracted twice with 200 ml of chloroform. The extract was dried over magnesium sulfate and concentrated under a reduced pressure, and resulting residue was applied to a silica gel column and eluted with chloroform/methanol (100:1 to 50:1), to obtain 4.52 g of the title compound as yellow crystals.

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