Реакция #58206

Уравнение реакции

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide

hydrochloric acid

sodium hydroxide

→

oily product

Выход 94.0%

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]amine

Выход 94.0%

Условия реакции

Обработка

1. 1
   ТемператураThe mixture is refluxed for 4 hours
2. 2
   Температураcooled in an ice bath
3. 3
   Экстракцияextracted three times with ethyl acetate
4. 4
   ПромывкаThe combined extracts are washed with water and with brine
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   Другоеevaporated under reduced pressure

Методика

4 g (12.9 mmol) of N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide are poured into 13 mL of 5N hydrochloric acid. The mixture is refluxed for 4 hours and then cooled in an ice bath, basified with 35% sodium hydroxide and extracted three times with ethyl acetate. The combined extracts are washed with water and with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. 3.2 g of oily product are obtained (94% yield).

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