Реакция #580540

Уравнение реакции

cyclohexanol

pyridine

2-bromopropionyl chloride

→

2-bromo-propionic acid cyclohexyl ester

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe product was partitioned between hexane and 10% citric acid
2. 2
   ДругоеThe organic phase was separated
3. 3
   Сушкаdried over MgSO4
4. 4
   Концентрированиеconcentrated

Методика

To a mixture of cyclohexanol (10.9 g, 10.9 mmol), pyridine (8.62 g, 10.9 mmol) in dichloromethane was added 2-bromopropionyl chloride (18.53 g, 10.9 mmol) at 0° C. The resulting mixture was stirred at room temperature for 1 hr. The product was partitioned between hexane and 10% citric acid. The organic phase was separated, dried over MgSO4 and concentrated to yield 2-bromo-propionic acid cyclohexyl ester, which was used in the following reaction without further purification.

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