Реакция #58017

Уравнение реакции

6-bromohexanol

THF

cinnamoyl chloride

→

6-bromohexyl cinnamate

Выход 53.0%

Растворители

triethylamine

Условия реакции

Обработка

1. 1
   Другоеat 0° C
2. 2
   ФильтрацияThe resultant was filtered
3. 3
   Другоеto remove the solvent
4. 4
   Другоеthe residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5)

Методика

7 g of 6-bromohexanol was dissolved in a mixed solution of 5 ml of triethylamine as base and 50 ml of THF, and then, cinnamoyl chloride was added dropwise thereto at 0° C. The resultant was filtered to remove the solvent and the residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5) to obtain 8 g of 6-bromohexyl cinnamate (yield: 53%).

Источник