Реакция #57939

Уравнение реакции

2-(4-tert-butyl-benzoylamino)-4-nitro-benzoic acid methyl ester

→

4-amino-2-(4-tert-butyl-benzoylamino)-benzoic acid methyl ester

Выход 76.2%

Растворители

ethyl acetate

ethyl acetate

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered through celite and silica washing with ethyl acetate
2. 2
   Концентрированиеconcentrated in vacuo
3. 3
   ДругоеThe residue was purified by flash chromatography

Методика

To a Parr shaker bottle was added 10% Pd/C (0.346 g) then ethyl acetate (50 mL) followed by 2-(4-tert-butyl-benzoylamino)-4-nitro-benzoic acid methyl ester (3.041 g, 8.53 mmol) as a solution in ethyl acetate (200 mL). The reaction was hydrogenated overnight, filtered through celite and silica washing with ethyl acetate and concentrated in vacuo. The residue was purified by flash chromatography using ethyl acetate/hexanes (20/80) to afford 4-amino-2-(4-tert-butyl-benzoylamino)-benzoic acid methyl ester (2.122 g, 76%) as a yellow solid.

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