Реакция #577213

Уравнение реакции

4-cyano-4′-hydroxybiphenyl

bromide

potassium carbonate

butanone

→

4-allyloxy-4′-cyanobiphenyl

Растворители

Water

Условия реакции

Обработка

1. 1
   ДругоеA reaction mixture obtained
2. 2
   Температураwas refluxed for 7 hours
3. 3
   Другоеwas then separated
4. 4
   ПромывкаAn organic layer was washed with water
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   Другоеto obtain a residue, which
8. 8
   Другоеwas purified by silica gel column chromatography
9. 9
   Другоеsubjected to recrystallization from ethanol

Методика

A reaction mixture obtained by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of ally bromide and 25 g of potassium carbonate to 250 mL of butanone was refluxed for 7 hours. Water was added to the reaction mixture, which was then separated. An organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a residue, which was purified by silica gel column chromatography using toluene as an elusion solvent and then subjected to recrystallization from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

Источник