Реакция #577201

ord-299061f69bee4fb9876effab7bb462f9

Уравнение реакции

Cl
HCl
N=C(N)NCCC[C@H](N)C(=O)O
arginine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.N=C(N)NCCC[C@H](N)C(=O)O
ceftriaxone
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.N=C(N)NCCC[C@H](N)C(=O)O
ceftriaxone arginine
NCCCC[C@H](N)C(=O)O
lysine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1
ceftriaxone
NCCCC[C@H](N)C(=O)O
lysine
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1.NCCCC[C@H](N)C(=O)O
ceftriaxone lysine

Растворители

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

About 610 mg (3.34 mole) of lysine was dissolved in 50 ml of distilled water. Additionally, 1.0 gram (1.67 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. The solution containing arginine was adjusted with 1N-HCl until the solution reached pH 6.0. The ceftriaxone solution was then added to the lysine solution and stirred by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-lysine solution. To the ceftriaxone-lysine solution was added about 400 mg of carrageenan and the solution was stirred by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-lysine-carrageenan hydrogel was formed. The hydrogel was then freeze-dried while in the swollen state, yielding about 1.92 g of the freeze-dried complex.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07527807B2uspto-grants-2009_05