Реакция #57653

Уравнение реакции

3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid tert-butyl ester

TFA dichloromethane

→

3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid

Выход 92.8%

Условия реакции

Обработка

1. 1
   ДругоеThe solvents were removed under vacuum
2. 2
   Другоеthe residue was triturated with ether
3. 3
   ФильтрацияFiltration

Методика

To 140 mg 3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid tert-butyl ester was added 4 mL of TFA/dichloromethane (1:1). The solution was stirred at room temperature for 5 h. The solvents were removed under vacuum and the residue was triturated with ether. Filtration gave 107 mg of 3-methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid as a white solid.

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