Реакция #576190

ord-4200b7c4456846cf8925f872926debba

Уравнение реакции

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O[C@H](C(=O)OCCl)C(C)C
Chloromethyl 2-(N-benzyloxycarbonyl-L-valyloxy)-3-methyl-(S)-(+)-butyrate
[I-]
iodide
→
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O[C@H](C(=O)OCI)C(C)C
title compound
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O[C@H](C(=O)OCI)C(C)C
Iodomethyl 2-(N-benzyloxycarbonyl-L-valyloxy)-3-methyl-(S)-(+)-butyrate

Реактанты

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O[C@H](C(=O)OCCl)C(C)C
Chloromethyl 2-(N-benzyloxycarbonyl-L-valyloxy)-3-methyl-(S)-(+)-butyrate
[I-]
iodide

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Chloromethyl 2-(N-benzyloxycarbonyl-L-valyloxy)-3-methyl-(S)-(+)-butyrate was converted to iodide by the method described in Example A-I-1, step e to give the title compound (3.64 g) practically pure. Rf (2% MeOH/CHCl3) 0.85.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06974802B2uspto-grants-2005_12