Реакция #57602

Уравнение реакции

3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester

ethyl 3-methyl-4-hydroxy-5-ethylbenzofuran-2-carboxylate

benzyl bromide

→

5-ethyl-4-benzyloxy-3-methylbenzofuran-2-carboxylic acid ethyl ester

Выход 99.8%

Условия реакции

Методика

According to the procedure of Example 86, Step 3, 0.250 g (1.01 mmol) of 3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester (Example 86, Step 2) and 0.599 mL (5.04 mmol) of benzyl bromide gave 0.341 g of 5-ethyl-4-benzyloxy-3-methylbenzofuran-2-carboxylic acid ethyl ester after chromatography on silica gel eluting with ethyl acetate/hexanes (1:20).

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