Реакция #57560

Уравнение реакции

4-bromoaniline

benzofuran-2-carboxylic acid chloride

triethylamine

→

N-(4-bromophenyl)-1-benzofuran-2-carboxamide

Выход 82.6%

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   Температураcooled in ice bath
2. 2
   ПромывкаThe dichloromethane layer was washed with water, 1N HCl, water and brine
3. 3
   Сушкаdried over Na2SO4
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated in vacuo

Методика

To 1.72 g of 4-bromoaniline was added to 1.89 g of benzofuran-2-carboxylic acid chloride in 35 mL of dichloromethane cooled in ice bath, followed by the addition of 4.9 mL of triethylamine. The reaction was stirred at room temperature overnight and then diluted with dichloromethane. The dichloromethane layer was washed with water, 1N HCl, water and brine, dried over Na2SO4, filtered, and concentrated in vacuo to provide 2.61 g of N-(4-bromophenyl)-1-benzofuran-2-carboxamide as a yellow solid. Yield 72%. m.p. 178-180° C.; MS: 314.1(M−H)−.

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